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Ending the HIV/AIDS Epidemic December 26, 2017

Hasty Passage of the Tax and Health Care Bill December 22, 2017 – With the hasty passage of the tax and health care bill passed along party lines yesterday afternoon, Congress has sent a clear message on how they prioritize communities living with and vulnerable to HIV, tuberculosis (TB), and hepatitis C virus (HCV) in the upcoming mid-term election year.

Hasty Passage of the Tax and Health Care Bill December 22, 2017

TAG Statement on Forbidden Words in Budget Documents December 20, 2017 – Treatment Action Group (TAG) joins the chorus of rational voices expressing outrage at reports that HHS agencies have received instructions to avoid words unpalatable to the Trump administration in their budget requests.

TAG Statement on Forbidden Words in Budget Documents December 20, 2017

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December 18, 2017
– On December 13, 2017, TAG participated in a hearing in Geneva, Switzerland to brief members of the Human Rights Council on human rights concerns in the United Arab Emirates (UAE).

TAG Statement to Human Rights Council on Human Rights Concerns in the UAE December 18, 2017

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December 14, 2017
– The first ever phase III trials for multidrug-resistant TB (MDR-TB) finally yielded results. Treatment Action Group (TAG), ACTION, and the Drug-Resistant TB Treatment Scale-up Action Team (DR-TB STAT) presented the results in a Webinar held on December 12, 2017.

Webinar: Exploring the Implications of the Delamanid Phase III and STREAM Trial Results December 14, 2017

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December 14, 2017
– On October 12, 2017, in Guadalajara, Mexico, Treatment Action Group, Advanced Access Delivery, Harvard Medical School, Partners In Health, and the Stop TB Partnership sponsored a symposium in conjunction with the Union World Conference on Lung Health.

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December 14, 2017
– ATAG information sheet on the current state of research into curing HIV infection.

HIV Cure Research Information Sheet December 14, 2017

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NEWS ON THE FIGHT TO END HIV/AIDS, VIRAL HEPATITIS, AND TUBERCULOSIS

TAGline Fall 2017

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Nearly complete genome sequences of three novel RNA viruses were acquired from the stool of an Afghan child. Phylogenetic analysis indicated that these viruses belong to the picorna-like virus superfamily. Because of their unique genomic organization and deep phylogenetic roots, we propose these viruses, provisionally named calhevirus, tetnovirus-1, and tetnovirus-2, as prototypes of new viral families. A newly developed nucleotide composition analysis (NCA) method was used to compare mononucleotide and dinucleotide frequencies for RNA viruses infecting mammals, plants, or insects. Using a large training data set of 284 representative picornavirus-like genomic sequences with defined host origins, NCA correctly identified the kingdom or phylum of the viral host for >95% of picorna-like viruses. NCA predicted an insect host origin for the 3 novel picorna-like viruses. Their presence in human stool therefore likely reflects ingestion of insect-contaminated food. As metagenomic analyses of different environments and organisms continue to yield highly divergent viral genomes NCA provides a rapid and robust method to identify their likely cellular hosts.

Citation information in Europe Pubmed Central

To investigate the frequency of oseltamivir resistance in circulating strains of the 2009 influenza A(H1N1) pandemic virus in Scotland, 1,802 samples from 1,608 infected hospitalised patients were screened by the H275Y discriminatory RT-PCR. Among these, we identified 10 patients who developed the H275Y mutation. All of them were immunocompromised and were under treatment or had been treated previously with oseltamivir.

Citation information in Europe Pubmed Central

Rhinovirus infections are the most common cause of viral illness in humans, and there is increasing evidence of their etiological role in severe acute respiratory tract infections (ARTIs). Human rhinoviruses (HRVs) are classified into two species, species A and B, which contain over 100 serotypes, and a recently discovered genetically heterogeneous third species (HRV species C). To investigate their diversity and population turnover, screening for the detection and the genetic characterization of HRV variants in diagnostic respiratory samples was performed by using nested primers for the efficient amplification of the VP4-VP2 region of HRV (and enterovirus) species and serotype identification. HRV species A, B, and C variants were detected in 14%, 1.8%, and 6.8%, respectively, of 456 diagnostic respiratory samples from 345 subjects (6 samples also contained enteroviruses), predominantly among children under age 10 years. HRV species A and B variants were remarkably heterogeneous, with 22 and 6 different serotypes, respectively, detected among 73 positive samples. Similarly, by using a pairwise distance threshold of 0.1, species C variants occurring worldwide were provisionally assigned to 47 different types, of which 15 were present among samples from Edinburgh, United Kingdom. There was a rapid turnover of variants, with only 5 of 43 serotypes detected during both sampling periods. By using divergence thresholds and phylogenetic analysis, several species A and C variants could provisionally be assigned to new types. An initial investigation of the clinical differences between rhinovirus species found HRV species C to be nearly twice as frequently associated with ARTIs than other rhinovirus species, which matches the frequencies of detection of respiratory syncytial virus. The study demonstrates the extraordinary genetic diversity of HRVs, their rapid population turnover, and their extensive involvement in childhood respiratory disease.

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A travel through history
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The University Library has a large collection of manuscripts, everything from complete collections named after their former owners or contents, to manuscripts arranged by subject.
An autograph book that once belonged to the German humanist Daniel Hermann (1543–1601).

Some examples of what you can find in our manuscript collections:

Among the oldest manuscripts is a collection of approximately 800 papyruses from Egypt, written in Greek during the centuries around the birth of Christ. The content of the fragments is varied: a passage from the Iliad, private letters, an astronomic calendar, receipts, tenancy documents, etc.

A papyrus fragment describing a magic formula for curing illnesses.

The oldest preserved Nordic manuscript, Necrologium Lundense, Lund’s registry of deaths, is also in the University Library. It is part of a collection of medieval manuscripts covering approximately 70 volumes, of which several come from the old library of Lund Cathedral. Most of the manuscripts are in Latin but there are also texts in other languages such as Syrian, Greek, Russian, Flemish, German, French, Danish and Swedish.

A sheet from Liber daticus vetustior – also known as the martyrologium of the Lund cathedral – from around 1135.

Oriental manuscripts have been incorporated in the University Library collections since the start of the 1700s. In the 1980s, language scholar and ambassador Gunnar Jarring donated his collection of manuscripts from East Turkestan to the library. It consists of approximately 600 manuscripts from the present-day province of Xinjiang in western China, which has been the home of the muslim Uyghur people of Central Asia for 1000 years. The Uyghur culture had no printed books until well into the 1900s so these manuscripts, mainly from the 1800s but also earlier, constitute its only written record. They cover everything from manuals for rain-making to pilgrim handbooks and cosmographic works. Parts of the collection were compiled by Jarring himself during his many trips to the region, while others came with the Swedish missionaries who were active there between 1894 and 1938. The University Library’s collection of Uyghur manuscripts is one of the most extensive in the world.

I’d go back to Tokyo… And, I probably wouldn’t leave.

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If I could fly anywhere right now, I would choose PDX. I got an email from Chloe at Reading Frenzy this morning about a Kickstarter project to fund the new edition of Crap Hound and it reminded me that I still have two of Sean’s books that he loaned me twelve years ago. I’d throw these gorgeous old 1950s medical textbooks into that Bean suitcase from Wejetset and brave the long flight from Scotland to return those books to their rightful owner.

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I would take a flight and head the New Zealand, the country that I have been wishing to visit for ages.

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I want to visit my family and friends up in Seattle. It’s been far too long.

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